产地国家：日本 处 方 药：是 所属类别：2克/袋 84袋/盒 包装规格：2克/袋 84袋/盒 计价单位：盒 生产厂家中文参考译名：田辺三菱製薬 生产厂家英文名：Mitsubishi 原产地英文商品名：KREMEZIN Fine Granules( クレメジン細粒)2g/Granules 84Granules/sachets 原产地英文药品名：Spherical suction charcoal 中文参考商品译名：炭素颗粒( クレメジン細粒)2克/袋 84袋/盒 中文参考药品译名：球形活性炭

简介

英文药名：KREMEZIN Fine Granules(Spherical suction charcoal) 中文药名：碳素粉(球形吸着炭細粒) 生产厂家：田边三菱 治疗类别名称：慢性肾功能衰竭 有效成分 予含2G(通过还原处理和氧化在高温下的球形碳质吸附剂得到的石油烃衍生的球形微细多孔碳)的球形碳质吸附剂中的一个包。 药效药理 1.对慢性肾功能衰竭的效果 (1) 当给予肾衰竭大鼠模型，获得肾衰竭条件恶化抑制(维护食品消费，体重，增加血清肌酐，尿素氮的抑制，抑制减少肾小球滤过功能，恶化抑制肾组织病变的)，生存时间延长 (2) 当施用于透析前慢性肾功能衰竭患者中，血清肌酐升高受到抑制，尿毒症症状改善，时间到透析被延长 作用机序 这种药物，慢性肾功能衰竭和吸附在胃肠道中通过口服尿毒症毒素，通过随着粪便排泄被，导致延迟的改善和透析的尿毒症症状的效果 适合病症 尿毒症 肾衰竭 用法用量 成年人：每日分口服三次，每次2克口服给药 劑型/包裝 クレメジン細粒分包2g*84包 生产厂家：田边三菱 产品特点 1.疗效好,副作用低： 本品原研单位于1978年起对球形活性炭进行了临床药效学和安全性研究。自1978至1998年间，经 460家医疗机构参与，受试者人数达2720例。 临床试验总结证明，球形活性炭颗粒可使肾功能衰竭受试者的血清肌酐值倒数对时间的斜率显著改善，透析间期延长，临床尿毒症症状显著改善。AST-120口服后不良反应发生率较低，经1852例受试者安全性统计，有111例(占受试者5.99%)发生160件不良反应，主要不良反应有便秘、食欲不振、恶心呕吐、腹胀、腹痛、腹泻、瘙痒等胃肠道和皮肤反应;其中有9例临床检验值异常;361例长期受试者中有2例腹痛和GOT、GPT升高，以上不良反应通过停药、继续给药或减少用药，使症状好转或消失，未发现后遗症、死亡等严重不良反应。 2.接受力强： 球形活性炭是市场应用最广泛的一种慢性肾功能不全治疗药物,临床实践的良好结果进一步强化了原有用药患者和医生的认同意识,使患者更容易接受本品。 据日本三共制药公司2006年市场预测报告，在日本有超过30万慢性肾病患者，韩国10万，美国50万，仅在我国沿海省市，就有超过30万的慢性肾病患者，据此推测，我国目前约有超过100万慢性肾功能不全患者，且每年以8-10%的速度递增，多数病人未能得到有效治疗。 本品由日本吴羽化学公司制造，商品名为 “KREMEZIN”的口服药用高性能沥青基球形活性炭，被用作治疗慢性肾衰竭和肾功能不全的药物，取得了良好的疗效。

英文版说明书

Brand name : KREMEZIN Fine Granules 2g Active ingredient: Spherical carbon adsorbent obtained by oxidizing and reducing spherical activated carbon at high temperature, which is derived from hydrocarbon from petroleum. Dosage form: black fine granules Print on wrapping: クレメジン細粒分包2g, KREMEZIN Effects of this medicine In patients with chronic renal failure, this medicine adsorbs uremic toxins in the gastrointestinal tract, so that they are excreted in the feces. This alleviates uremic symptoms such as loss of appetite, bad breath, nausea and itchiness, making it possible to delay initiation of dialysis. Usually, it is used to alleviate uremic symptoms and delay dialysis initiation in patients with progressive chronic renal failure. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. •If you are patients with gastrointestinal obstruction. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <> •In general, for adults, take 1 packet (2 g of the active ingredient) three times a day. Strictly follow the instructions. •If you are currently taking any other medicines, do not take them at the same time; you should try to leave 30 minutes to 1 hour after taking the other medicine before taking this medicine. However, there may be differences in the effectiveness of medicines between individuals and between different medicines, so sufficient consideration should be given to the effects of the other medicine. •If you miss a dose, take a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.