奥拉帕尼片Lynparza Tablets 150mg(olaparib)
[caption id="attachment_18297" align="alignleft" width="300"]
奥拉帕尼片Lynparza Tablets 150mg(olaparib)[/caption]
药店国别：
产地国家：美国
处方药：是
所属类别： 150毫克/片 60片/瓶
包装规格： 150毫克/片 60片/瓶
计价单位：瓶
生产厂家中文参考译名：
生产厂家英文名：AstraZeneca/Merck
原产地英文商品名：Lynparza 150mg/tablets 60tablets/bottle
原产地英文药品名：olaparib
中文参考商品译名：Lynparza口服片剂 150毫克/片 60片/瓶
中文参考药品译名：奥拉帕尼
曾用名：
简介：近日，美国食品和药物管理局(FDA)批准了PARP抑制剂LYNPARZA(olaparib 中文名：奥拉帕尼)如下：LYNPARZA片剂的新用途，用于对复发性，上皮性卵巢癌，输卵管癌或原发性腹膜癌患者进行维持治疗，这些患者对铂类化疗有完全或部分反应，无论BRCA状态如何;LYNPARZA片剂的新用途(每日两次2片)，而不是胶囊(8粒，每日两粒);LYNPARZA片剂现在也表明(从目前加速批准转换)用于成年患有有害或疑似有害生殖系BRCA突变(gBRCA)晚期卵巢癌的患者，这些患者已接受过三次或更多次化疗前的治疗;根据FDA批准的伴随诊断选择用于该适应症的患者进行治疗。批准日期：2017年8月17日 公司：阿斯利康LYNPARZA(奥拉帕尼[olaparib])片剂，用于口服美国最初批准：2014年最近的重大变化
作用机制
Lynparza是聚(ADP-核糖)聚合酶(PARP)酶的抑制剂，包括PARP1，PARP2和PARP3。PARP酶参与正常细胞功能，例如DNA转录和DNA修复。Olaparib已经显示出在体外抑制选择的肿瘤细胞系的生长并且在人癌症的小鼠异种移植模型中减少肿瘤生长，作为单一疗法或基于铂的化学疗法。在用olaparib处理后增加的细胞毒性和抗肿瘤活性在细胞系和小鼠肿瘤模型中被注意到，其中BRCA和非BRCA蛋白缺陷参与DNA损伤的同源重组修复(HRR)并与铂反应相关。 体外研究表明，奥拉帕尼诱导的细胞毒性可能涉及抑制PARP酶活性和增加PARP-DNA复合物的形成，导致DNA损伤和癌细胞死亡。
适应症和用法:
Lynparza是一种聚(ADP-核糖)聚合酶(PARP)抑制剂，表明：卵巢癌•用于对有害或疑似有害生殖系统或体细胞BRCA突变(g BRCAm或sBRCAm)晚期上皮卵巢，输卵管或原发性腹膜癌的成人患者进行维持治疗，这些患者对一线铂类化疗完全或部分应答。选择患有g BRCAm晚期上皮卵巢，输卵管或原发性腹膜癌的患者，根据FDA批准的Lynparza伴随诊断进行治疗。•用于复发上皮性卵巢癌，输卵管癌或原发性腹膜癌的成人患者的维持治疗，这些患者对铂类化疗有完全或部分反应。
•用于治疗患有有害或疑似有害生殖系统的BRCA突变(g BRCAm)晚期卵巢癌的成年患者，这些患者已接受过三次或更多次化疗前的治疗。根据FDA批准的Lynparza伴随诊断选择患者进行治疗。乳腺癌•对于在新辅助，辅助或转移性环境中接受化疗治疗的有害或疑似有害g BRCAm，人表皮生长因子受体2(HER2)阴性转移性乳腺癌的患者。激素受体(HR)阳性乳腺癌患者应该接受先前的内分泌治疗或被认为不适合进行内分泌治疗。根据FDA批准的Lynparza伴随诊断选择患者进行治疗。
剂量和给药:
•推荐的片剂剂量为300毫克，每天口服两次，有或没有食物。
•对于不良反应，请考虑剂量中断或剂量减少。•对于中度肾功能损害(CLcr 31-50 mL/min)，每日两次减少剂量至200 mg。
剂量形式和强度片剂：
150mg，100mg
禁忌症:
没有。
警告和注意事项:
•骨髓增生异常综合征/急性髓性白血病(MDS/AML)：在接触Lynparza单药治疗的患者中发生率<1.5%且大多数事件都有致命的结果。在基线和之后每月监测患者的血液毒性。如果确认MDS / AML，则停止。•肺炎：在接触Lynparza的患者中发生率<1%，有些病例是致命的。怀疑是肺炎的中断治疗。如果确诊肺炎则停止。•胚胎-胎儿毒性：Lynparza可导致胎儿伤害。建议胎儿的潜在风险并使用有效的避孕措施。
不良反应:
•临床试验中最常见的不良反应(≥10%)为恶心，乏力(包括虚弱)，贫血，呕吐，腹痛，头晕，腹泻，中性粒细胞减少，白细胞减少，鼻咽炎/上呼吸道感染/流感，呼吸道感染，关节痛/肌痛，味觉障碍，头痛，消化不良，食欲减退，便秘和口腔炎。•最常见的实验室异常(≥25%)是血红蛋白减少，平均红细胞体积增加，淋巴细胞减少，白细胞减少，绝对中性粒细胞计数减少，血清肌酐增加和血小板减少。
药物相互作用:
•CYP3A抑制剂：避免同时使用强效或中度CYP3A抑制剂。如果不能避免抑制剂，减少奥拉帕尼剂量。•CYP3A诱导剂：避免同时使用强效或中度CYP3A诱导剂，因为可能会降低疗效。
用于特定人群哺乳期：
建议女性不要母乳喂养。
包装提供/存储和处理提供:
Lynparza有150毫克和100毫克片剂。•150毫克片剂：绿色至绿色/灰色，椭圆形，双凸面，薄膜包衣片，一面凹陷'OP150'，背面凹面平整，有：瓶装60粒(NDC 0310-0679-60)瓶装120片(NDC 0310-0679-12)。•100毫克片剂：黄色至深黄色，椭圆形，双凸面，薄膜包衣片，一面凹陷'OP100'，另一面凹凸，有：瓶装60粒(NDC 0310-0668-60)和瓶装120片(NDC 0310-0668-12)。
存储:
储存温度为20ºC至25ºC(68ºF至77ºF)，允许偏差为15ºC至30ºC(59ºF至86ºF)[见USP受控室温]。 存放在原瓶中以防潮。
奥拉帕尼片英文版说明书:
LYNPARZA®(olaparib)Consumer Medicine InformationWhat is in this leafletThis leaflet answers some common questions about LYNPARZA tablets. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.All medicines have risks and benefits. Your doctor has weighed the risks of you taking LYNPARZA tablets against the benefits they expect it will have for you.If you have any concerns about taking this medicine, ask your doctor or pharmacist.Keep this leaflet with the medicine.You may need to read it again.What LYNPARZA tablets are used forYou will have been prescribed LYNPARZA tablets if you have ovarian cancer and it has responded to treatment with platinum-based chemotherapy or if you have a certain type of breast cancer (germline BRCA-mutated, human epidermal growth factor receptor 2-negative (HER2-negative)) which has spread beyond the original tumour. A genetic test will be done to determine if you have germline BRCA mutated breast cancer.LYNPARZA belongs to a group of medicines called PARP (Poly (ADP-Ribose) Polymerase enzymes) inhibitors. PARP inhibitors can destroy cancer cells that are not good at repairing DNA damage. These specific cancer cells can be identified by response to platinum chemotherapy or by looking for faulty DNA repair genes such as BRCA (BReast CAncer) genes.Ask your doctor if you have any questions about why this medicine has been prescribed for you.Your doctor may have prescribed it for another reason.This medicine is available only with a doctor's prescription.Before you take LYNPARZA tabletsWhen you must not take itDo not take LYNPARZA tablets if you have an allergy to:any of the ingredients listed at the end of this leaflet.Some of the symptoms of an allergic reaction may include:shortness of breathwheezing or difficulty breathingswelling of the face, lips, tongue or other parts of the bodyrash, itching or hives on the skin.Do not take this medicine if you are pregnant or if you (male or female) are planning to have a baby.It may affect your developing baby if you take it during pregnancy. Your doctor will advise women to ensure they are using effective contraception when using the medicine and for at least 1 month after stopping the medicine. Male patients and their partners must use effective contraception when using the medicine for at least 3 months after stopping the medicine.Do not breast-feed if you are taking this medicine.It is not known if the active ingredient in LYNPARZA tablets passes into breast milk. Breast-feeding mothers are advised not to breast-feed during treatment with LYNPARZA tablets and for one month after receiving the last dose.Do not give this medicine to children.Safety and effectiveness in children younger than 18 years have not been established.Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.If it has expired or is damaged, return it to your pharmacist for disposal.If you are not sure whether you should start taking this medicine, talk to your doctor.Before you start to take itTell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.Tell your doctor if you have or have had any of the following medical conditions:problems with your kidneys or liver (renal or hepatic impairment)problems with your blood (e.g. anaemia, low white blood cell counts).Tell your doctor if you are pregnant or plan to become pregnant or are breast-feeding.If you are a man, tell your doctor if you are planning to have a baby with your partner.Your doctor can discuss with you the risks and benefits involved. Whether you are male or female, your doctor will advise you to use an effective form of contraception while taking LYNPARZA and for at least 1 month for women and 3 months for men after stopping treatment. Female partners of male patients taking LYNPARZA must also use a suitable method of contraception. Male patients must not donate sperm whilst taking LYNPARZA and for 3 months after stopping treatment.If you have not told your doctor about any of the above, tell them before you start taking LYNPARZA tablets.Taking other medicinesTell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.You should not take LYNPARZA if you are taking any other anti-cancer agents.Some medicines or foods and LYNPARZA may interfere with each other and reduce effectiveness. These include:medicines used to treat fungal infections (antifungals) with active ingredients such as fluconazole, ketoconazole, itraconazolemedicines used to treat bacterial infections (antibiotics) with active ingredients such as clarithromycin, rifampicin, rifabutin, ciprofloxacin, erythromycinmedicines used to treat viral infections (especially HIV) with active ingredients such as ritonavir, indinavir, saquinavir, nevirapine, boceprevir, cobicistat, etravirine and efavirenzmedicines used to treat epilepsy with active ingredients such as phenytoin, carbamazepinemedicines with active ingredients such as modafinil used to treat a sleep disorder called narcolepsy (where you may experience very sleepy periods at odd times during the day)medicines to treat high blood pressure, angina (chest pain), irregular heartbeat or heart failure such as diltiazem, digoxin, furosemide, valsartan and verapamilmedicines called statins used to treat high cholesterol such as rosuvastatin and atorvastatinmedicines used to treat diabetes, such as glibenclamide and metforminbosentan, a medicine used to treat high blood pressure in the lungsmedicines used to suppress the immune system, such as ciclosporin, tacrolimus and sirolimusfentanyl, a medicine used to treat cancer painmethotrexate, a medicine used to treat cancer, rheumatoid arthritis and psoriasisquetiapine, a medicine used to treat mental disorderscolchicine, a medicine used to treat goutdabigatran, a medicine to prevent blood clotsgrapefruit, Seville oranges and star fruitSt John's Wort, used to treat depression.Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.If you have not told your doctor about any of these things, tell them before you take any LYNPARZA tablets.How to take LYNPARZA tabletsYour doctor has prescribed LYNPARZA tablets for you. Please note LYNPARZA is also available as a 50 mg capsule. The doses of LYNPARZA tablets and capsules are not the same. Taking the wrong dose or a capsule instead of a tablet could lead to LYNPARZA not working properly or to more side effects.Follow all directions given to you by your doctor or pharmacist carefully.They may differ from the information contained in this leaflet.If you do not understand the instructions on the pack, ask your doctor or pharmacist for help.How much to takeThe usual dose is two 150 mg tablets taken twice each day (a total of 4 tablets each day).Your doctor may prescribe a different dose if you have problems with your kidneys, or are taking certain medicines that may interact with LYNPARZA tablets or if you experience certain side effects while you are taking LYNPARZA tablets.Your doctor will tell you how many tablets of LYNPARZA to take and it is important that you take the total recommended daily dose.How to take itSwallow the tablets whole with a glass of water. Do not chew, crush, dissolve or divide the tablets as this may affect how quickly the drug gets into your body.When to take itTake LYNPARZA tablets at about the same time each morning and evening.Taking it at the same time each day will have the best effect. It will also help you remember when to take it.LYNPARZA tablets can be taken with or without food.How long to take itContinue taking your medicine for as long as your doctor tells you.It is important to keep taking your medicine even if you feel well.Continue taking your medicine until you finish the pack.If you forget to take itIf you forget to take
奥拉帕尼片Lynparza Tablets 150mg(olaparib)[/caption]
药店国别：
产地国家：美国
处方药：是
所属类别： 150毫克/片 60片/瓶
包装规格： 150毫克/片 60片/瓶
计价单位：瓶
生产厂家中文参考译名：
生产厂家英文名：AstraZeneca/Merck
原产地英文商品名：Lynparza 150mg/tablets 60tablets/bottle
原产地英文药品名：olaparib
中文参考商品译名：Lynparza口服片剂 150毫克/片 60片/瓶
中文参考药品译名：奥拉帕尼
曾用名：
简介：近日，美国食品和药物管理局(FDA)批准了PARP抑制剂LYNPARZA(olaparib 中文名：奥拉帕尼)如下：LYNPARZA片剂的新用途，用于对复发性，上皮性卵巢癌，输卵管癌或原发性腹膜癌患者进行维持治疗，这些患者对铂类化疗有完全或部分反应，无论BRCA状态如何;LYNPARZA片剂的新用途(每日两次2片)，而不是胶囊(8粒，每日两粒);LYNPARZA片剂现在也表明(从目前加速批准转换)用于成年患有有害或疑似有害生殖系BRCA突变(gBRCA)晚期卵巢癌的患者，这些患者已接受过三次或更多次化疗前的治疗;根据FDA批准的伴随诊断选择用于该适应症的患者进行治疗。批准日期：2017年8月17日 公司：阿斯利康LYNPARZA(奥拉帕尼[olaparib])片剂，用于口服美国最初批准：2014年最近的重大变化
作用机制
Lynparza是聚(ADP-核糖)聚合酶(PARP)酶的抑制剂，包括PARP1，PARP2和PARP3。PARP酶参与正常细胞功能，例如DNA转录和DNA修复。Olaparib已经显示出在体外抑制选择的肿瘤细胞系的生长并且在人癌症的小鼠异种移植模型中减少肿瘤生长，作为单一疗法或基于铂的化学疗法。在用olaparib处理后增加的细胞毒性和抗肿瘤活性在细胞系和小鼠肿瘤模型中被注意到，其中BRCA和非BRCA蛋白缺陷参与DNA损伤的同源重组修复(HRR)并与铂反应相关。 体外研究表明，奥拉帕尼诱导的细胞毒性可能涉及抑制PARP酶活性和增加PARP-DNA复合物的形成，导致DNA损伤和癌细胞死亡。
适应症和用法:
Lynparza是一种聚(ADP-核糖)聚合酶(PARP)抑制剂，表明：卵巢癌•用于对有害或疑似有害生殖系统或体细胞BRCA突变(g BRCAm或sBRCAm)晚期上皮卵巢，输卵管或原发性腹膜癌的成人患者进行维持治疗，这些患者对一线铂类化疗完全或部分应答。选择患有g BRCAm晚期上皮卵巢，输卵管或原发性腹膜癌的患者，根据FDA批准的Lynparza伴随诊断进行治疗。•用于复发上皮性卵巢癌，输卵管癌或原发性腹膜癌的成人患者的维持治疗，这些患者对铂类化疗有完全或部分反应。
•用于治疗患有有害或疑似有害生殖系统的BRCA突变(g BRCAm)晚期卵巢癌的成年患者，这些患者已接受过三次或更多次化疗前的治疗。根据FDA批准的Lynparza伴随诊断选择患者进行治疗。乳腺癌•对于在新辅助，辅助或转移性环境中接受化疗治疗的有害或疑似有害g BRCAm，人表皮生长因子受体2(HER2)阴性转移性乳腺癌的患者。激素受体(HR)阳性乳腺癌患者应该接受先前的内分泌治疗或被认为不适合进行内分泌治疗。根据FDA批准的Lynparza伴随诊断选择患者进行治疗。
剂量和给药:
•推荐的片剂剂量为300毫克，每天口服两次，有或没有食物。
•对于不良反应，请考虑剂量中断或剂量减少。•对于中度肾功能损害(CLcr 31-50 mL/min)，每日两次减少剂量至200 mg。
剂量形式和强度片剂：
150mg，100mg
禁忌症:
没有。
警告和注意事项:
•骨髓增生异常综合征/急性髓性白血病(MDS/AML)：在接触Lynparza单药治疗的患者中发生率<1.5%且大多数事件都有致命的结果。在基线和之后每月监测患者的血液毒性。如果确认MDS / AML，则停止。•肺炎：在接触Lynparza的患者中发生率<1%，有些病例是致命的。怀疑是肺炎的中断治疗。如果确诊肺炎则停止。•胚胎-胎儿毒性：Lynparza可导致胎儿伤害。建议胎儿的潜在风险并使用有效的避孕措施。
不良反应:
•临床试验中最常见的不良反应(≥10%)为恶心，乏力(包括虚弱)，贫血，呕吐，腹痛，头晕，腹泻，中性粒细胞减少，白细胞减少，鼻咽炎/上呼吸道感染/流感，呼吸道感染，关节痛/肌痛，味觉障碍，头痛，消化不良，食欲减退，便秘和口腔炎。•最常见的实验室异常(≥25%)是血红蛋白减少，平均红细胞体积增加，淋巴细胞减少，白细胞减少，绝对中性粒细胞计数减少，血清肌酐增加和血小板减少。
药物相互作用:
•CYP3A抑制剂：避免同时使用强效或中度CYP3A抑制剂。如果不能避免抑制剂，减少奥拉帕尼剂量。•CYP3A诱导剂：避免同时使用强效或中度CYP3A诱导剂，因为可能会降低疗效。
用于特定人群哺乳期：
建议女性不要母乳喂养。
包装提供/存储和处理提供:
Lynparza有150毫克和100毫克片剂。•150毫克片剂：绿色至绿色/灰色，椭圆形，双凸面，薄膜包衣片，一面凹陷'OP150'，背面凹面平整，有：瓶装60粒(NDC 0310-0679-60)瓶装120片(NDC 0310-0679-12)。•100毫克片剂：黄色至深黄色，椭圆形，双凸面，薄膜包衣片，一面凹陷'OP100'，另一面凹凸，有：瓶装60粒(NDC 0310-0668-60)和瓶装120片(NDC 0310-0668-12)。
存储:
储存温度为20ºC至25ºC(68ºF至77ºF)，允许偏差为15ºC至30ºC(59ºF至86ºF)[见USP受控室温]。 存放在原瓶中以防潮。
奥拉帕尼片英文版说明书:
LYNPARZA®(olaparib)Consumer Medicine InformationWhat is in this leafletThis leaflet answers some common questions about LYNPARZA tablets. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.All medicines have risks and benefits. Your doctor has weighed the risks of you taking LYNPARZA tablets against the benefits they expect it will have for you.If you have any concerns about taking this medicine, ask your doctor or pharmacist.Keep this leaflet with the medicine.You may need to read it again.What LYNPARZA tablets are used forYou will have been prescribed LYNPARZA tablets if you have ovarian cancer and it has responded to treatment with platinum-based chemotherapy or if you have a certain type of breast cancer (germline BRCA-mutated, human epidermal growth factor receptor 2-negative (HER2-negative)) which has spread beyond the original tumour. A genetic test will be done to determine if you have germline BRCA mutated breast cancer.LYNPARZA belongs to a group of medicines called PARP (Poly (ADP-Ribose) Polymerase enzymes) inhibitors. PARP inhibitors can destroy cancer cells that are not good at repairing DNA damage. These specific cancer cells can be identified by response to platinum chemotherapy or by looking for faulty DNA repair genes such as BRCA (BReast CAncer) genes.Ask your doctor if you have any questions about why this medicine has been prescribed for you.Your doctor may have prescribed it for another reason.This medicine is available only with a doctor's prescription.Before you take LYNPARZA tabletsWhen you must not take itDo not take LYNPARZA tablets if you have an allergy to:any of the ingredients listed at the end of this leaflet.Some of the symptoms of an allergic reaction may include:shortness of breathwheezing or difficulty breathingswelling of the face, lips, tongue or other parts of the bodyrash, itching or hives on the skin.Do not take this medicine if you are pregnant or if you (male or female) are planning to have a baby.It may affect your developing baby if you take it during pregnancy. Your doctor will advise women to ensure they are using effective contraception when using the medicine and for at least 1 month after stopping the medicine. Male patients and their partners must use effective contraception when using the medicine for at least 3 months after stopping the medicine.Do not breast-feed if you are taking this medicine.It is not known if the active ingredient in LYNPARZA tablets passes into breast milk. Breast-feeding mothers are advised not to breast-feed during treatment with LYNPARZA tablets and for one month after receiving the last dose.Do not give this medicine to children.Safety and effectiveness in children younger than 18 years have not been established.Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.If it has expired or is damaged, return it to your pharmacist for disposal.If you are not sure whether you should start taking this medicine, talk to your doctor.Before you start to take itTell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.Tell your doctor if you have or have had any of the following medical conditions:problems with your kidneys or liver (renal or hepatic impairment)problems with your blood (e.g. anaemia, low white blood cell counts).Tell your doctor if you are pregnant or plan to become pregnant or are breast-feeding.If you are a man, tell your doctor if you are planning to have a baby with your partner.Your doctor can discuss with you the risks and benefits involved. Whether you are male or female, your doctor will advise you to use an effective form of contraception while taking LYNPARZA and for at least 1 month for women and 3 months for men after stopping treatment. Female partners of male patients taking LYNPARZA must also use a suitable method of contraception. Male patients must not donate sperm whilst taking LYNPARZA and for 3 months after stopping treatment.If you have not told your doctor about any of the above, tell them before you start taking LYNPARZA tablets.Taking other medicinesTell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.You should not take LYNPARZA if you are taking any other anti-cancer agents.Some medicines or foods and LYNPARZA may interfere with each other and reduce effectiveness. These include:medicines used to treat fungal infections (antifungals) with active ingredients such as fluconazole, ketoconazole, itraconazolemedicines used to treat bacterial infections (antibiotics) with active ingredients such as clarithromycin, rifampicin, rifabutin, ciprofloxacin, erythromycinmedicines used to treat viral infections (especially HIV) with active ingredients such as ritonavir, indinavir, saquinavir, nevirapine, boceprevir, cobicistat, etravirine and efavirenzmedicines used to treat epilepsy with active ingredients such as phenytoin, carbamazepinemedicines with active ingredients such as modafinil used to treat a sleep disorder called narcolepsy (where you may experience very sleepy periods at odd times during the day)medicines to treat high blood pressure, angina (chest pain), irregular heartbeat or heart failure such as diltiazem, digoxin, furosemide, valsartan and verapamilmedicines called statins used to treat high cholesterol such as rosuvastatin and atorvastatinmedicines used to treat diabetes, such as glibenclamide and metforminbosentan, a medicine used to treat high blood pressure in the lungsmedicines used to suppress the immune system, such as ciclosporin, tacrolimus and sirolimusfentanyl, a medicine used to treat cancer painmethotrexate, a medicine used to treat cancer, rheumatoid arthritis and psoriasisquetiapine, a medicine used to treat mental disorderscolchicine, a medicine used to treat goutdabigatran, a medicine to prevent blood clotsgrapefruit, Seville oranges and star fruitSt John's Wort, used to treat depression.Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.If you have not told your doctor about any of these things, tell them before you take any LYNPARZA tablets.How to take LYNPARZA tabletsYour doctor has prescribed LYNPARZA tablets for you. Please note LYNPARZA is also available as a 50 mg capsule. The doses of LYNPARZA tablets and capsules are not the same. Taking the wrong dose or a capsule instead of a tablet could lead to LYNPARZA not working properly or to more side effects.Follow all directions given to you by your doctor or pharmacist carefully.They may differ from the information contained in this leaflet.If you do not understand the instructions on the pack, ask your doctor or pharmacist for help.How much to takeThe usual dose is two 150 mg tablets taken twice each day (a total of 4 tablets each day).Your doctor may prescribe a different dose if you have problems with your kidneys, or are taking certain medicines that may interact with LYNPARZA tablets or if you experience certain side effects while you are taking LYNPARZA tablets.Your doctor will tell you how many tablets of LYNPARZA to take and it is important that you take the total recommended daily dose.How to take itSwallow the tablets whole with a glass of water. Do not chew, crush, dissolve or divide the tablets as this may affect how quickly the drug gets into your body.When to take itTake LYNPARZA tablets at about the same time each morning and evening.Taking it at the same time each day will have the best effect. It will also help you remember when to take it.LYNPARZA tablets can be taken with or without food.How long to take itContinue taking your medicine for as long as your doctor tells you.It is important to keep taking your medicine even if you feel well.Continue taking your medicine until you finish the pack.If you forget to take itIf you forget to take
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