产地国家：美国 处 方 药：是 所属类别：100毫克/粒 30粒/盒 包装规格：100毫克/粒 30粒/盒 计价单位：盒 生产厂家中文参考译名：艾伯维制药 生产厂家英文名：AbbVie Inc 原产地英文商品名：Gengraf 100mg/Capsules 30Capsules/box 原产地英文药品名：cyclosporine capsules USP[MODIFIED] 中文参考商品译名：Gengraf胶囊 100毫克/粒 30粒/盒 中文参考药品译名：环孢菌素

简介

部份中文环孢菌素处方资料(仅供参考) 英文名：cyclosporine capsules USP 商品名：Gengraf Capsules 中文名：环孢菌素胶囊 生产商：艾伯维制药 用途分类：其他免疫抑制剂 药理 环孢素胶囊的主药环孢素(也称环孢菌素A)为11个氨基酸组成的环状多肽。本品是一种强效的免疫抑制剂，可逆地特异作用于淋巴细胞。动物实验表明环孢素可延长同种异体器官(皮肤、心脏、肾脏、胰脏、骨髓、小肠和肺)移植的存活时间，抑制细胞介导免疫反应(包括同种异体免疫反应、迟发性皮肤过敏反应、实验性变应性脑脊髓炎、弗氏佐剂性关节炎、移植物抗宿主反应和依赖T-细胞的抗体生成)。本品尚能抑制淋巴因子(包括ⅠL-2)的合成和释放、阻断淋巴细胞生长周期中的G0期和G1早期阶段。本品不抑制红细胞生成，亦不影响吞噬细胞功能。使用本品患者与使用其他免疫抑制剂患者相比感染发生率较低。 适应症 1.适用于预防同种异体肾、肝、心、骨髓等器官或组织移植所发生的排斥反应，也适用于预防及治疗骨髓移植时发生的移植物抗宿主反应(GVHD)。 2.经其它免疫抑制剂治疗无效的狼疮肾炎、难治性肾病综合症等自身免疫性疾病。 用法用量 1.器官移植：采用三联免疫抑制方案时，起始剂量6～11mg/kg/日，并根据血药浓度调整剂量，根据血药浓度每2周减量0.5～1 mg/kg/日，维持剂量2～6mg/kg/日，分2次口服。在整个治疗过程，必须在有免疫抑制治疗经验医生的指导下进行。 2.骨髓移植：预防移植物抗宿主病：移植前一天起先用环孢素注射液，2.5mg/kg/日，分2次静脉滴注，待胃肠反应消失后(约0.5～1月)，改服本品，起始剂量6mg/kg/日，分2次口服，一月后缓慢减量，总疗程半年。 3.治疗移植物抗宿主病：单独或在原用肾上腺皮质激素基础上加用本品，2～3mg/kg/日，分2次口服，待病情稳定后缓慢减量，总疗程半年以上。 4.狼疮肾炎、难治性肾病综合征：初始剂量4～5 mg/kg/日，分2次口服，出现明显疗效后缓慢减量至2～3 mg/kg/日，疗程3～6月以上。

英文版说明书

Gengraf Capsules(cyclosporine capsules) GENGRAF Capsules (cyclosporine capsules, USP[MODIFIED])and GENGRAF® Oral Solution(cyclosporine oral solution, USP[MODIFIED])are prescription medicines used to help prevent organ rejection in people who have received a kidney, liver, or heart transplant. Cyclosporine (MODIFIED) has been used with other immunosuppressants, such as azathioprine and corticosteroids. IMPORTANT SAFETY INFORMATION WARNING While you are on this treatment, it is important to be under the care of a doctor who has experience treating and monitoring organ transplant patients who are taking medicines like GENGRAF. GENGRAF is an immunosuppressant, a drug that reduces the body’s ability to fight illness and disease. Immunosuppressant drugs may increase your chances of getting an infection and certain types of cancers. In organ transplant patients, using GENGRAF with other immunosuppressants may increase this effect. Different formulations of cyclosporine deliver different amounts of medicine. Do not switch formulations of cyclosporine without your doctor’s permission and direction, as switching formulations may require a dosage change. GENGRAF can cause high blood pressure and kidney problems. This risk increases the longer you take GENGRAF and with higher doses. Ongoing laboratory tests must be performed to monitor your kidney function while you are being treated with GENGRAF. Do not take GENGRAF if you are allergic to cyclosporine or any of the ingredients in GENGRAF. Occasionally patients have developed a condition that causes damage to the small blood vessels, which may result in graft failure. Occasionally some patients have experienced abnormally high levels of potassium in their blood. Cases of liver damage, including liver failure, have been reported in patients treated with cyclosporine. In some cases, fatal outcomes have been reported. Most reports included patients who also had other medical conditions. Ongoing laboratory tests must be performed to monitor your liver function while you are being treated with GENGRAF. Patients receiving immunosuppressants, including cyclosporine, are at an increased risk of developing lymphomas and other types of cancers, especially skin cancers. Some of these cancers may be fatal. You should avoid excess sun exposure, including tanning booths. Transplant patients taking cyclosporine are at an increased risk for serious infections, some of which may have fatal outcomes. Infections may include the polyoma virus, which may have a serious and sometimes fatal outcome. There have been reports of convulsions (uncontrolled shaking of the body) in patients taking cyclosporine and, in particular, in patients also taking high doses of corticosteroids. High blood pressure is a common side effect of taking cyclosporine. During treatment with cyclosporine, vaccination may be less effective, and the use of vaccines containing live viruses should be avoided. You should take GENGRAF exactly as prescribed by your physician. This includes taking your medication on the same schedule every day. You should avoid grapefruit and grapefruit juice while taking GENGRAF. Tell your doctor about any other medications, vitamins, nutritional supplements, or herbal products you are taking. GENGRAF and other medicines may affect each other, causing side effects. GENGRAF may affect the way other medicines work, and other medicines may affect how GENGRAF works. If you are or are planning to become pregnant, tell your doctor right away and follow the instructions you receive about taking GENGRAF. The most common side effects include kidney problems, high blood pressure, abnormal hair growth on your body or face, tremor, headache, nausea, vomiting, swollen or painful gums, low number of white blood cells, urinary tract infections, and other infections. https://www.rxabbvie.com/pdf/gengraf-cap.pdf