醋酸甲羟孕酮Hysron-H Tab(Medroxyprogesterone Acetate)

药店国别: 产地国家:日本 处方药:所属类别: 200毫克/片 100片/盒 包装规格: 200毫克/片 100片/盒 计价单位:生产厂家中文参考译名: 生产厂家英文名:Kyowa Hakko Kirin 原产地英文商品名:Hysron-H Tab(ヒスロンH錠)200mgtab 1000tabs/box 原产地英文药品名:Medroxyprogesterone Acetate 中文参考商品译名:Hysron-H(ヒスロンH錠)200毫克/片 100片/盒 中文参考药品译名:醋酸甲羟孕酮

简介

部份中文醋酸甲羟孕酮资料(仅供参考) 类别名称:抗肿瘤口服促黄体激素制剂 商标名:Hysron-H Tab. 200mg 一般名:メドロキシプロゲステロン酢酸エステルMedroxyprogesterone Acetate 化学名:17-Hydroxy-6α-methyl-4-pregnene-3, 20-dione acetate略名MPA 分子式:C24H34O4 分子量:386.52化学構造式 性状:白色至淡黄白色结晶性粉末,无臭味。可溶性它易溶于氯仿中,易溶略微丙酮或1,4-二恶烷,稍稍溶于乙腈或正丁基氯化铵,甲醇,乙醇(99.5),或微溶于乙醚,并在水或己烷几乎不溶。熔点204〜209℃ 药效药理 1. 抗肿瘤作用 (1)预防乳腺癌的抗肿瘤活性对DMBA诱发的大鼠乳腺癌,观察到由24,60,120mg/kg的口服给药剂量依赖性的抗肿瘤作用。使用培养的人乳腺癌细胞MCF-7和其他莫昔芬耐药株的R-27的结果检查两种菌株的E2(雌二醇)的存在下的集落形成能力,10-8〜10-5mol/L的效果而不管在它显示出浓度依赖性的细胞生长抑制作用。如对人乳腺癌细胞的ZR-75-1的影响的结果,研究了细胞计数,而不管E2的存在,显示出浓度依赖性细胞抑制效应在10-10和10-5mol/ L时,一效果是在存在比E2不存在的E2更强。 (2) 对子宫内膜癌的抗肿瘤效果作用对子宫内膜腺癌细胞的AD-30移植到裸鼠0.1,10,100mg/千克/调查经口给药的日经结果的肿瘤倍增时间显著延长每个治疗组中观察到,所述组织与细胞的萎缩崩溃的组织学,没有观察到流体成分的腺腔的贮存器。 2. 作用机序DNA合成抑制作用,据表达该抗肿瘤作用是由于抑制作用和抗雌激素作用的垂体 - 肾上腺 - 性腺系统上。 适应症 乳腺癌,子宫内膜癌 用法用量 乳腺癌,成人每日口服600〜1200毫克。子宫内膜癌成人每日口服400〜600毫克,以2-3倍的醋酸甲羟孕酮。此外,根据症状进行调整 包装规格 片剂:200毫克:100片(10片×10)[PTP] 制造商 麒麟有限公司

英文版说明书

Brand name:Hysron-H Tablets 200 mg Active ingredient: Medroxyprogesterone acetate Dosage form: White tablets, diameter 9.0 mm, thickness 3.5 mm Print on wrapping: KH405 HYSH 200 mgEffects of this medicineThis medicine, a type of female hormone (luteal hormone), inhibits proliferation of hormone-dependent tumor cells by suppressing secretion of hormones that act on the pituitary gland and stimulate ovaries.It is usually used in the treatment of breast cancer and uterine body cancer (endometrial cancer).Before using this medicine, be sure to tell your doctor and pharmacist•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.If you are within 1 week after surgery.If you have thrombotic disease (cerebral infarction, myocardial infarction, thrombophlebitis) (including history of the disease), arteriosclerosis, heart disease (heart valve disease, atrial fibrillation, endocarditis, heart failure, etc.).If you are administering hormones. If you have undiagnosed genital bleeding, urinary tract bleeding or breast lesion, liver disorder or hypercalcaemia.•If you are pregnant or breastfeeding.•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)Dosing schedule (How to take this medicine)•Your dosing schedule prescribed by your doctor is <>•Breast cancer: In general, for adults, take 1 to 2 tablets [200 to 400 mg of the active ingredient] 3 times daily.Uterine body cancer (endometrial cancer): In general, for adults, take 400 to 600 mg of the active ingredient in 2 or 3 devided doses daily. This preparation contains 200 mg of the active ingredient in a tablet.The dosage may be adjusted according to the symptoms. Strictly follow the instructions.•If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.•Do not stop taking this medicine unless your doctor instructs you to do so.Precautions while taking this medicine• Possible adverse reactions to this medicineThe most commonly reported adverse reactions include weight gain, moon face, uterine bleeding, edema, thrombosis, menstruation disorder and vision disorder. If any of these symptoms occur, consult with your doctor or pharmacist.The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.•foot pain/swelling, chest pain, vomiting blood [thrombosis]•shortness of breath/breathing difficulty, general swelling, general malaise [congestive heart failure]•shortness of breath/breathing difficulty, swelling around eyes and lips, hives [anaphylactoid symptoms]•reduced visual acuity, bulging eyes, double vision, migraine [papilledema]The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.Storage conditions and other information•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.•Discard the remainder. Do not store them.Kyowa Hakko Kirin Co.,LtdInternalPublished: 8/2012The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
用药温馨提示:当您服用此药物时,需定期接受医疗专业人士的检查,以便随时针对其药效、副作用等情况进行监测。本网站所包含的信息旨在为患者提供帮助,不能代替医学建议和治疗。
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