产地国家：日本 　处 方 药：是 　所属类别：5毫克/片 1000片/盒 　包装规格：5毫克/片 1000片/盒 　计价单位：盒 　生产厂家中文参考译名：田边三菱制药 　生产厂家英文名：Tanabe Mitsubishi Pharmaceutical 原产地英文商品名：SERMION(サアミオン錠)5mg/Tablets 1000Tablets/box 原产地英文药品名：Nicergoline 中文参考商品译名：思尔明(サアミオン錠)5毫克/片 1000片/盒 中文参考药品译名：尼麦角林

简介

部份中文尼麦角林处方资料(仅供参参考) 英文名：Nicergoline 商品名：SERMION Tablets 中文名：尼麦角林 剂 型：片剂 生产商：田辺三菱 サアミオン錠5mg/サアミオン散1% 药效分类：大脑循环代谢改善剂 批准日期：2006年6月 商標名：SERMION Tablets 5mg 一般名：ニセルゴリン(Nicergoline) 化学名：[(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-bromopyridine-3-carboxylate 分子式：C24H26BrN3O3 分子量：484.39 性状 ·白色—淡黄色的结晶或结晶性的粉末。 乙酰胆碱(99.5)或无水醋酸稍微容易溶化，几乎不溶于水。 ·根据光逐渐变成淡褐色。 ·熔点:136分解。 药效药理 1.脑循环改善作用 ·脑血管障碍患者中，内颈以及椎骨动脉的血流量增加，并且空洞血病巢部的脑血流增加被认定。 ·根据能力使猫的下颚动脉搏血流量增加。 2.血液流动性改善作用 ·对于健康成人及脑血管障碍患者，通过adp、胶原蛋白等的血小板凝聚抑制作用及红血球变形功能亢进作用被认可。 3.神经传达的作用 ·在鼠中，在大脑皮质和海马中恢复因年龄增长而下降的脑内甲乙酰转移酶(cat)活性和乙酰胆碱受体的结合能力。 ·鼠恢复因年龄增长而下降的海马的乙酰胆碱游离。 ·乙酰胆碱(ache)有选择性的肾上腺素酶抑制剂，在老鼠的体内ache活动力和海马乙酰胆碱量的增加作用。 ·在小白鼠中，连续口服使多巴胺的代谢旋转的促进作用被认可。 4.脑能量代谢改善作用 ·在老鼠的脑缺血模型及低氧模型中，表示对脑能量代谢障碍的改善作用。 ·在成熟和老龄鼠的脑梗塞模型中，对葡萄糖的摄入和消费有改善的作用。 5.脑神经功能改善作用 ·在老鼠的脑缺血模型和低氧模型中，表示对脑故障的保护作用。 ·在老鼠海马ca1区域神经细胞中，表示低阈值(t -type)钙通道截断作用。 ·以零食鼠的过性脑虚血模型为例，抑制海马ca1区域神经细胞的迟发性坏死. ·在老龄鼠的脑梗塞模型及小鼠的斯科普拉明的健忘症模型中，表现出了对学习、记忆障碍的改善作用。 6.脑波改善作用 对于脑血管障碍患者来说，其脑波异常的改善得到了认可。 适应症 改善因脑梗塞后遗症引起的慢性脑循环障碍而引起的意欲低下。 用法与用量 通常，把1天15毫克的成年人，分成3次服用。另外，根据年龄、症状适当增减。 包装 片剂 5毫克:100片(10片×10)，500片(10片×50)，1000片(10片×100)，2,100片(21片×100)，500片(瓶装) 散1% 30g(0.5克×600包) 散1%：100g 制造商 田辺三菱株式会社 注：以上中文处方资料不够完整，使用者以原处方资料为准。

英文版说明书

Brand name : SERMION Tablet 5mg Active ingredient: Nicergoline Dosage form: white tablet, diameter 6.2 mm, thickness 3.0 mm Print on wrapping: サアミオン, Sermion, 5 mg, TA129 Effects of this medicine This medicine increases cerebral bood flow, improves cerebral energy metabolism, and inhibit platelet aggregation. These actions improve cerebral circulation and metabolism. It is usually used to improve avolition caused by chronic cerebrovascular disorder associated with cerebral infarction sequelae. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you are suspected that the haemostasis of intracranial haemorrhage has not been established. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is << to be written by a healthcare professional>> •In general, for adults, take 1 tablet (5 mg of the active ingredient) at a time, 3 times a day. It shoud be adjusted according to your age and symptoms. Strictly follow the instructions. •If you miss a dose, take a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine • Possible adverse reactions to this medicine The most commonly reported adverse reactions include nausea, rash, headache, loss of appetite, diarrhea, constipation and abdominal pain. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. No pertinent entries. The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store away from direct sunlight, heat and moisture. •Discard the remainder. Do not store them.