产地国家：美国 处 方 药：是 所属类别：100单位/毫升 10毫升/瓶 包装规格：100单位/毫升 10毫升/瓶 计价单位：瓶 生产厂家中文参考译名: 诺和诺德 生产厂家英文名: NOVO NORDISK INC 原产地英文商品名: NOVOLIN R 100IU/ML 10ML/VIAL 原产地英文药品名: INSULIN SUSP ISOPHANE RECOMBINANT HUMAN 中文参考商品译名: 诺和灵R 100单位/毫升 10毫升/瓶 中文参考药品译名: 人重组低精蛋白胰岛素悬浮液

简介

部份中文Novolin处方资料(仅供参考) 诺和灵：Novolin 分类 胰岛素及其他影响血糖药 药理作用 本品可调节糖谢，促进葡萄糖透过细胞膜进入细胞，促使组织中葡萄糖的氧化分解、糖元合成和转变为脂肪、氨基酸;抑制肝糖元分解和糖元异生，从而使血糖降低;抑制脂肪分解，使酮体生成减少，纠正酮症酸血症的各种症状;促进蛋白质的合成，抑制蛋白质分解。在其促进葡萄糖进入细胞合成糖元时，的合蛋白质分解。在其促进葡萄糖进入细胞合成糖元时，可将K+也带入细胞，故可和葡萄糖同用，治疗高血钾，也可与葡萄糖、氯化钾合用纠正细胞内缺K+，治疗心肌梗塞时的心律失常。本品主要用于各型糖尿病、糖尿病酮症、酸血症及糖尿病昏迷将其与胰高血糖素合用，可促进肝细胞再生，治疗重症肝炎。 药代动力 皮下注射吸收迅速。不同产品在作用快慢与持续长短上可有差异。范围为0.5-1.5h起效，1-5dh作用达高峰，作用持续8-24h。主要在肝、肾破坏，严重肾功能损害比肝病时对胰岛素消除速率的影响大。静注后作用出现快，但消失也快。 适应症 适应地需要胰岛素治疗的糖尿病病人。 用法用量 根据不同产品和病情适当调整剂量。一般除治疗糖尿病性昏迷等急症外，多采用皮下注射。以诺和灵30R为例，于饭前30min注射，剂量须因人而定，中型病例开始4-212U/次，重型病例则12-24U/次，并根据临床症状、血糖和尿糖水平进行调整。按每日尿糖总量计算，每2g尿糖给胰岛素1单位或按体重计算每超过正常血糖总量2g给胰岛素1单位。所需胰岛素单位=体重(kg)×1000×0.6×(血糖量-0.1÷100)÷2式中0.6表示体液占体重的百分数;0.1表示血糖正常值。治疗糖尿病酮症酸血症时，最好采用低量连续输入法，以减少低血钾和防止严重低血糖，开始可静注0.33U/kg体重，随之按7U/h速度给药，如4h内无任何改善，应给予大剂量(200-400U)。肾衰病人用胰岛素时应减量，肾小球过滤率(GFR)为10-50ml/min时，剂量应相应减少至GFR<10ml/min时，剂量减少50%。治重症肝炎，可将胰岛素2~10U加胰高血糖素1mg置10%葡萄糖液中，静脉滴注2次/d。诺和灵30R瓶装胰岛素使用时应上、下翻转药瓶，待胰岛素成为均匀的白色混悬液，立即用注射器抽出开始注射。笔芯胰岛素须将笔芯放入诺和笔后上下颠倒混匀，调整剂量，开始注射。笔芯卡式瓶装仅供单人使用，注射后，应按住注射按钮，让针头在皮下停留几秒钟直至针头从皮肤拔出，以确保胰岛素完全注入。 不良反应 ①过敏反应：使用诺和灵30R很少发生过敏反应，特殊病例可能会发生局部或全身性皮疹、水泡，一般出现时间短暂，可自行消退，脂肪萎缩罕见。②低血胰岛素注射过量，或未及时进餐，或运动量增加时，可能会有低血糖发生，若病人清醒应口服葡萄糖;若病人失去知觉，应用胰高血糖素治疗(肌肉或皮下注射)或静脉注射葡萄糖。 注意事项 ①同时使用甲状腺素、皮质类固醇、利尿剂、苯妥英钠等或口服避孕药时，会增加对胰岛素的需求。Β-受体阻断剂和单胺氧化酶抑制剂也会影响胰岛素用量。 ②转换用药：从使用高度纯化的猪或人胰岛素改为使用单组份人胰岛素，可维持剂量不变。从使用牛或混合来源的胰岛素改用本品时，需要降低剂量10%，换用期间应密切监测病人的血糖。 ③瓶装胰岛素于2-8℃保存，在室温条件下可保存6周。笔芯胰岛素可随身携带1个月。本品在摇动后不呈均匀的白色混悬液，不可使用。装有笔芯和诺和笔不应放冰箱中。本品过期应弃之。 制剂 诺和灵人胰岛素(rDNA)系列，见下表：诺和灵N40iu/ml10ml支诺和灵R40iu/ml10ml支诺和灵30R40iu/ml10ml支诺和灵R笔芯100iu/ml3ml支诺和灵N笔芯100iu/ml3ml支诺和灵30R笔芯100iu/ml3ml支诺和灵III笔芯　支诺和灵30G(针头)7*盒诺和灵50R笔芯100iu/ml3ml支 注 诺和笔(NovoPen)：由两部分组成， ①如钢笔大小的注射器. ②置换卡式胰岛素小瓶.特点是不需携带多量针筒和药瓶，不需抽取及混合胰岛素，自动控制注射量精确安全，注射几乎不觉疼痛。

英文版说明书

Generic Name: insulin regular (IN soo lin REG yoo lar)Brand Names: Humulin R, Novolin R, Novolin R Innolet, Novolin R PenFill, ReliOn/Novolin R What is Novolin R (insulin regular)? Insulin is a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Insulin regular is a long-acting form of insulin that is slightly different from other forms of insulin that are not man-made. Insulin regular is used to treat diabetes. Insulin regular may also be used for other purposes not listed in this medication guide. What is the most important information I should know about Novolin R (insulin regular)? Take care to keep your blood sugar from getting too low, causing hypoglycemia. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, or trouble concentrating. Carry a piece of non-dietetic hard candy or glucose tablets with you in case you have low blood sugar. Also be sure your family and close friends know how to help you in an emergency. Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, loss of appetite, increased urination, nausea, vomiting, drowsiness, dry skin, and dry mouth. Check your blood sugar levels and ask your doctor how to adjust your insulin doses if needed. Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another. Insulin is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels. Do not change the brand of insulin or syringe you are using without first talking to your doctor or pharmacist. Some brands of insulin regular and syringes are interchangeable, while others are not. Your doctor and/or pharmacist know which brands can be substituted for one another. What should I discuss with my healthcare provider before using Novolin R (insulin regular)? Do not use this medication if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar). Before using insulin regular, tell your doctor if you have liver or kidney disease. Tell your doctor about all other medications you use, including any oral (by mouth) diabetes medications. Insulin regular is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels. Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments. FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether insulin regular passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I use Novolin R (insulin regular)? Use this medication exactly as it was prescribed for you. Do not use it in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label. Insulin regular is given as an injection (shot) under your skin. Your doctor, nurse, or pharmacist will give you specific instructions on how and where to inject this medicine. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Choose a different place in your injection skin area each time you use this medication. Do not inject into the same place two times in a row. Insulin regular should look as clear as water. Do not use the medication if has changed colors, looks cloudy, or has particles in it. Call your doctor for a new prescription. Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets. Some insulin needles can be used more than once, depending on needle brand and type. But a reused needle must be properly cleaned, recapped, and inspected for bending or breakage. Reusing needles also increases your risk of infection. Ask your doctor or pharmacist whether you are able to reuse your insulin needles. Do not change the brand of insulin or syringe you are using without first talking to your doctor or pharmacist. Some brands of insulin regular and syringes are interchangeable, while others are not. Your doctor and/or pharmacist know which brands can be substituted for one another. Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another. Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, or skip meals. These things can affect your glucose levels and your insulin dose needs may also change. Watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, loss of appetite, increased urination, nausea, vomiting, drowsiness, dry skin, and dry mouth. Check your blood sugar levels and ask your doctor how to adjust your insulin doses if needed. Ask your doctor how to adjust your insulin regular dose if needed. Do not change your dose without first talking to your doctor. Carry an ID card or wear a medical alert bracelet stating that you have diabetes, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are diabetic. Storing unopened vials and cartridges: Keep in the carton and store in a refrigerator, protected from light. Unopened vials may also be stored at room temperature, away from heat and bright light. Storing after your first use: Keep the "in-use" vials or cartridges at room temperature. Do not freeze insulin regular, and throw away the medication if it has become frozen. Throw away any insulin not used before the expiration date on the medicine label. What happens if I miss a dose? Since insulin regular is used before meals or snacks, you may not be on a timed dosing schedule. Whenever you use insulin regular, be sure to eat a meal or snack within 15 to 30 minutes. Do not use extra insulin to make up a missed dose. It is important to keep insulin regular on hand at all times. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. An insulin overdose can cause life-threatening hypoglycemia. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, seizure (convulsions), or coma. What should I avoid while using Novolin R (insulin regular)? Do not change the brand of insulin regular or syringe you are using without first talking to your doctor or pharmacist. Avoid drinking alcohol. Your blood sugar may become dangerously low if you drink alcohol while using insulin regular. Novolin R (insulin regular) side effects Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out. Hypoglycemia, or low blood sugar, is the most common side effect of insulin. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, or seizure (convulsions). Watch for signs of low blood sugar. Carry a piece of non-dietetic hard candy or glucose tablets with you in case you have low blood sugar. Tell your doctor if you have itching, swelling, redness, or thickening of the skin where you inject insulin. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect Novolin R (insulin regular)? Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following: •albuterol (Proventil, Ventolin); •clonidine (Catapres); •reserpine; •guanethidine (Ismelin); or •beta-blockers such as atenolol (Tenormin), bisoprolol (Zebeta), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), timolol (Blocadren), and others. There are many other medicines that can increase or decrease the effects of insulin on lowering your blood sugar. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. Where can I get more information? •Your pharmacist can provide more information about insulin regular. •Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. •Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2006 Cerner Multum, Inc. Version: 5.01. Revision Date: 04/24/2009 1:52:45 PM. •Novolin R Prescribing Information (FDA) •Novolin R InnoLets MedFacts Consumer Leaflet (Wolters Kluwer) •Humulin R Vials MedFacts Consumer Leaflet (Wolters Kluwer) •Humulin R Prescribing Information (FDA) •Humulin R (Concentrated) MedFacts Consumer Leaflet (Wolters Kluwer)