华法令钾_Warfarin_华法令钾颗粒说明书
[caption id="attachment_40005" align="alignleft" width="300"]
Warfarin Granules 0.2%.100g（Warfarin Potassium 华法令钾颗粒）[/caption]
药店国别：
产地国家：日本
处 方 药：是
所属类别：100克/瓶
包装规格：100克/瓶
计价单位：瓶
生产厂家中文参考译名:卫材制药
生产厂家英文名:Eisai
原产地英文商品名:Warfarin Granules 100g//bottle
原产地英文药品名:Warfarin Potassium
中文参考商品译名:Warfarin 100克/瓶
中文参考药品译名:华法令钾
简介：
部份中文华法令钾处方资料(仅供参考)
商品名：Warfarin Granules 0.2%
英文名：Warfarin Potassium
中文名：华法令钾颗粒
生产商：卫材制药
药品简介
薬效分类名:経口抗凝固剤
批准日期：2004年 5月
商品名：Warfarin tablets
一般的名称:Warfarin Potassium
化学名:Monopotassium(1RS)-2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate
分子式:C19H15KO4
分子量:346.42
性状:
华法林钾是一种白色结晶粉末。
本产品很容易溶于水，易溶于乙醇(95)。
本产品溶解在氢氧化钠试液中。
本产品1.0g溶解在水中100mL的液体的pH值为7.2~8.3。
本产品因光线而变浅黄色。
本产品的水溶液(1~10)不表现出旋转光。
处理注意事项:
华法林片剂
玫瑰包装在打开后，保存光(可能允许变色和含量因光而降低) 此外，片剂 0.5mg PTP使用UV切割膜)。
片剂0.5mg，片剂5mg可能在片剂中出现棕色或红橙色斑点，但由使用染料。
华法林颗粒
打开后，遮挡光(可能允许由于光而降低含量)。
该剂，虽然白色粘附在颗粒表面可以看到，它是由于添加剂。
药理作用:
作用机制:
本药物通过抑制维生素K依赖性血液凝固因子(凝血素、第七、IX和X因子)的生物合成，在肝脏中对抗维生素K作用，表现出抗凝作用和抗血栓作用。
此外，PIVKA(由维塔明K absence或antagonist：蛋白酶前体)通过这种药物在血液中释放，具有抗凝作用和血栓形成抑制作用增加。
抗凝作用
这种药物，在口服2mg/kg的兔子后，观察到凝血酶时间的延长6-18小时。
血栓形成抑制作用
通过连接家禽的颈动脉形成血栓，以13~20mg/kg/周剂量施用10~30天，对血栓生长的影响进行了研究，血栓重量在抑制蛋白素活性15%以下的病例中显著减少。
适应病:治疗和预防血栓栓塞(静脉血栓形成、心肌梗死、肺栓塞、脑栓塞、脑血栓形成缓慢进展等)
用法与用量:
该剂，根据血液凝固能力测试(凝血素时间和血栓测试)的测试值，确定该剂的剂量，是一种在充分执行血液凝固能力管理的同时使用的药物。
口服后，每天口服一次初始剂量，通过血液凝固能力测试几天，以进入目标治疗区，确定维持剂量。
对华法林的敏感性是个体差异很大，因为同一个体可能会发生变化，定期进行血液凝固测试，并根据需要调整维持剂量。
当快速表达抗凝效果时，考虑在首次给药时使用肝素等。
成人的初始剂量，作为华法林钾，通常每天1~5mg一次。
儿童维持剂量(毫克/千克/天)的指南如下。
少于12个月：0.16毫克/千克/天
1岁及15岁以下：0.04至0.10毫克/千克/天
包装规格:片剂
0.5毫克：100片[10片 (PTP)×10]，100片(瓶，玫瑰)，500片(瓶，玫瑰)，1000 片[10片(PTP)×100]
1毫克：100片[10片(PTP)×10]，100片(瓶，玫瑰)，500片(瓶，玫瑰)，1000 片[10片(PTP)×100]
5毫克：100 片[10片(PTP)×10]，100片(瓶、玫瑰)
颗粒 0.2%
100克(瓶)
制造供应商:卫材有限公司
Warfarin Granules 0.2%(Warfarin Potassium)
Brand name :Warfarin Granules0.2%
Active ingredient:Warfarin potassium
Dosage form:
dark red granules
Print on wrapping:
Effects of this medicine
This medicine suppresses the function of vitamin K to inhibit blood clotting, and prevents a blood clot from forming.
It is usually used in the treatment and prevention of venous thrombosis, myocardial infarction, pulmonary embolism, cerebral embolism, cerebral thrombosis etc.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reaction(itch, rash etc.) to any medicine.
If you are taking capecitabine (Xeloda).
If you are bleeding or prone to bleeding.
If you have: hepatic disorder, renal disorder, malignant tumor, hyperthyroidism or hypothyroidism.
If you are immediately after undergoing a surgery or getting an injury, labor or miscarriage.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is ((to be written by a healthcare professional))
In general, the daily dosage will be determined by your doctor according to the findings of a blood coagulation test (prothrombin time, thrombotest and INR) etc.
The daily dosage for children will be also determined by your doctor according to the findings of a blood coagulation test. For infants under the age of 12 months: a standard of the maintenance dosage is 0.16 mg/kg/day. For children aged between 1 to under 15: a standard of the maintenance dosage is 0.04 to 0.10 mg/kg/day.
Strictly follow the instructions.
If you miss a dose, take a dose as soon as possible. However, if 12 hours or more has already passed since the scheduled time, skip the missed dose and continue your regular dosing schedule. You should take never two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Do not take foods and drinks containing vitamin K in large amount such as natto (fermented soybeans), chlorella, aojiru (green juice), and Saint John's Wort, since they may diminish the effect of the medicine.
Drinking alcohol may influence the effect of the medicine. Avoid drinking an excessive amount of alcohol while you are receiving the medicine.
The medicine has an action to prevent stopping bleeding. Avoid working or exercising which may lead to get injured.
Keep the appointment with your doctor and take a blood coagulation test regularly. If you need to undergo a surgery or tooth extraction, consult with your doctor beforehand. If you need to be seen in another medical facility, tell the doctor, dentist or pharmacist in the facility that you are taking the medicine.
The medicine has harmful effects to unborn babies. Avoid getting pregnant while you are receiving the medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, pruritus, erythema, hives, dermatitis, fever and hair loss. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
headache, chest pain, abdominal pain, black stool, hematochezia, hematuria, gum bleeding, subcutaneous hemorrhage [intraorgan hemorrhage such as cerebral hemorrhage, mucosal hemorrhage, subcutaneous hemorrhage]
flat red rash with pain, petechial hemorrhage, hemorrhagic blister [skin necrosis]
painful skin ulcers, painful bruises [calciphylaxis]
nausea, vomiting, loss of appetite, yellowing in the skin or conjunctiva ocular [hepatic dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep the medicine out of the reach of children. Store it away from light, heat and moisture.
Discard the remainder. Do not store them.
Internal
Revised: 9/2017
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Warfarin Granules 0.2%.100g（Warfarin Potassium 华法令钾颗粒）[/caption]
药店国别：
产地国家：日本
处 方 药：是
所属类别：100克/瓶
包装规格：100克/瓶
计价单位：瓶
生产厂家中文参考译名:卫材制药
生产厂家英文名:Eisai
原产地英文商品名:Warfarin Granules 100g//bottle
原产地英文药品名:Warfarin Potassium
中文参考商品译名:Warfarin 100克/瓶
中文参考药品译名:华法令钾
简介：
部份中文华法令钾处方资料(仅供参考)
商品名：Warfarin Granules 0.2%
英文名：Warfarin Potassium
中文名：华法令钾颗粒
生产商：卫材制药
药品简介
薬效分类名:経口抗凝固剤
批准日期：2004年 5月
商品名：Warfarin tablets
一般的名称:Warfarin Potassium
化学名:Monopotassium(1RS)-2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate
分子式:C19H15KO4
分子量:346.42
性状:
华法林钾是一种白色结晶粉末。
本产品很容易溶于水，易溶于乙醇(95)。
本产品溶解在氢氧化钠试液中。
本产品1.0g溶解在水中100mL的液体的pH值为7.2~8.3。
本产品因光线而变浅黄色。
本产品的水溶液(1~10)不表现出旋转光。
处理注意事项:
华法林片剂
玫瑰包装在打开后，保存光(可能允许变色和含量因光而降低) 此外，片剂 0.5mg PTP使用UV切割膜)。
片剂0.5mg，片剂5mg可能在片剂中出现棕色或红橙色斑点，但由使用染料。
华法林颗粒
打开后，遮挡光(可能允许由于光而降低含量)。
该剂，虽然白色粘附在颗粒表面可以看到，它是由于添加剂。
药理作用:
作用机制:
本药物通过抑制维生素K依赖性血液凝固因子(凝血素、第七、IX和X因子)的生物合成，在肝脏中对抗维生素K作用，表现出抗凝作用和抗血栓作用。
此外，PIVKA(由维塔明K absence或antagonist：蛋白酶前体)通过这种药物在血液中释放，具有抗凝作用和血栓形成抑制作用增加。
抗凝作用
这种药物，在口服2mg/kg的兔子后，观察到凝血酶时间的延长6-18小时。
血栓形成抑制作用
通过连接家禽的颈动脉形成血栓，以13~20mg/kg/周剂量施用10~30天，对血栓生长的影响进行了研究，血栓重量在抑制蛋白素活性15%以下的病例中显著减少。
适应病:治疗和预防血栓栓塞(静脉血栓形成、心肌梗死、肺栓塞、脑栓塞、脑血栓形成缓慢进展等)
用法与用量:
该剂，根据血液凝固能力测试(凝血素时间和血栓测试)的测试值，确定该剂的剂量，是一种在充分执行血液凝固能力管理的同时使用的药物。
口服后，每天口服一次初始剂量，通过血液凝固能力测试几天，以进入目标治疗区，确定维持剂量。
对华法林的敏感性是个体差异很大，因为同一个体可能会发生变化，定期进行血液凝固测试，并根据需要调整维持剂量。
当快速表达抗凝效果时，考虑在首次给药时使用肝素等。
成人的初始剂量，作为华法林钾，通常每天1~5mg一次。
儿童维持剂量(毫克/千克/天)的指南如下。
少于12个月：0.16毫克/千克/天
1岁及15岁以下：0.04至0.10毫克/千克/天
包装规格:片剂
0.5毫克：100片[10片 (PTP)×10]，100片(瓶，玫瑰)，500片(瓶，玫瑰)，1000 片[10片(PTP)×100]
1毫克：100片[10片(PTP)×10]，100片(瓶，玫瑰)，500片(瓶，玫瑰)，1000 片[10片(PTP)×100]
5毫克：100 片[10片(PTP)×10]，100片(瓶、玫瑰)
颗粒 0.2%
100克(瓶)
制造供应商:卫材有限公司
Warfarin Granules 0.2%(Warfarin Potassium)
Brand name :Warfarin Granules0.2%
Active ingredient:Warfarin potassium
Dosage form:
dark red granules
Print on wrapping:
Effects of this medicine
This medicine suppresses the function of vitamin K to inhibit blood clotting, and prevents a blood clot from forming.
It is usually used in the treatment and prevention of venous thrombosis, myocardial infarction, pulmonary embolism, cerebral embolism, cerebral thrombosis etc.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reaction(itch, rash etc.) to any medicine.
If you are taking capecitabine (Xeloda).
If you are bleeding or prone to bleeding.
If you have: hepatic disorder, renal disorder, malignant tumor, hyperthyroidism or hypothyroidism.
If you are immediately after undergoing a surgery or getting an injury, labor or miscarriage.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is ((to be written by a healthcare professional))
In general, the daily dosage will be determined by your doctor according to the findings of a blood coagulation test (prothrombin time, thrombotest and INR) etc.
The daily dosage for children will be also determined by your doctor according to the findings of a blood coagulation test. For infants under the age of 12 months: a standard of the maintenance dosage is 0.16 mg/kg/day. For children aged between 1 to under 15: a standard of the maintenance dosage is 0.04 to 0.10 mg/kg/day.
Strictly follow the instructions.
If you miss a dose, take a dose as soon as possible. However, if 12 hours or more has already passed since the scheduled time, skip the missed dose and continue your regular dosing schedule. You should take never two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Do not take foods and drinks containing vitamin K in large amount such as natto (fermented soybeans), chlorella, aojiru (green juice), and Saint John's Wort, since they may diminish the effect of the medicine.
Drinking alcohol may influence the effect of the medicine. Avoid drinking an excessive amount of alcohol while you are receiving the medicine.
The medicine has an action to prevent stopping bleeding. Avoid working or exercising which may lead to get injured.
Keep the appointment with your doctor and take a blood coagulation test regularly. If you need to undergo a surgery or tooth extraction, consult with your doctor beforehand. If you need to be seen in another medical facility, tell the doctor, dentist or pharmacist in the facility that you are taking the medicine.
The medicine has harmful effects to unborn babies. Avoid getting pregnant while you are receiving the medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, pruritus, erythema, hives, dermatitis, fever and hair loss. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
headache, chest pain, abdominal pain, black stool, hematochezia, hematuria, gum bleeding, subcutaneous hemorrhage [intraorgan hemorrhage such as cerebral hemorrhage, mucosal hemorrhage, subcutaneous hemorrhage]
flat red rash with pain, petechial hemorrhage, hemorrhagic blister [skin necrosis]
painful skin ulcers, painful bruises [calciphylaxis]
nausea, vomiting, loss of appetite, yellowing in the skin or conjunctiva ocular [hepatic dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep the medicine out of the reach of children. Store it away from light, heat and moisture.
Discard the remainder. Do not store them.
Internal
Revised: 9/2017
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
用药温馨提示：当您服用此药物时，需定期接受医疗专业人士的检查，以便随时针对其药效、副作用等情况进行监测。本网站所包含的信息旨在为患者提供帮助，不能代替医学建议和治疗。
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